Association of Dietary Fatty Acid Intake With Glaucoma in the United States

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Association of Dietary Fatty Acid Intake With Glaucoma in the United States

Ye Elaine Wang, MD1; Victoria L. Tseng, MD, PhD1; Fei Yu, PhD1,2; et al. Joseph Caprioli, MD1; Anne L. Coleman, MD, PhD1,3

JAMA Ophthalmol. 2018;136(2):141-147. doi:10.1001/jamaophthalmol.2017.5702

Key PointsQuestion  Does an association exist between daily dietary intake of polyunsaturated fatty acids, especially ω-3 fatty acids, and the risk of glaucoma in the US population?

Findings  In a cross-sectional population study of 3865 participants, increased daily levels of eicosapentaenoic acid and docosahexaenoic acid intake were associated with significantly lower risks of glaucoma. Daily levels of total polyunsaturated fatty acid intake in the higher quartiles, however, were associated with significantly increased odds of having glaucoma.

Meaning  These findings indicate that longitudinal studies or randomized clinical trials assessing potential ω-3 fatty acid (eicosapentaenoic acid and docosahexaenoic acid) protection against glaucoma are warranted.

Abstract
Importance  Identifying whether an association exists between daily dietary polyunsaturated fatty acid (PUFA) consumption and the prevalence of glaucoma in the United States may provide modifiable dietary risk factors for the development of glaucoma.

Objective  To analyze the association between glaucoma and daily dietary intake of PUFAs, including ω-3 fatty acids, in the US population.

Design, Setting, and Participants  Data from 3865 participants in the National Health and Nutrition Examination Survey (NHANES) 2005-2008 database who were 40 years or older, had participated in the vision health and dietary intake questionnaires, and had available results from laboratory tests and eye examinations that included frequency-doubling technology visual field loss detection tests and optic disc photographs were included. Data collection was performed by NHANES from 2005 to 2006. Data for the present study were downloaded from their database May 1 to 30, 2017. Data analyses were performed from June 1 to October 1, 2017.

Exposures  Daily dietary intake of PUFAs, including ω-3 fatty acids.

Main Outcomes and Measures  Prevalence of glaucoma in the United States as defined using the Rotterdam criteria, which included a combination of optic cupping or asymmetry and visual field defect results.

Results  Of the 83 643 392 weighted survey participants included in this cross-sectional study, 43 660 327 (52.2%) were women and 3 076 410 (3.7%) met our criteria for having glaucoma. Compared with participants without glaucoma, those with glaucoma were older (mean [SE] age, 61.4 [0.8] vs 53.7 [0.4] years; P < .001). Increased levels of daily dietary intake of eicosapentaenoic acid (odds ratio [OR], 0.06; 95% CI, 0.00-0.73) and docosahexaenoic acid (OR, 0.06; 95% CI, 0.01-0.87) were associated with significantly lower odds of having glaucoma. However, participants with daily total dietary PUFA intake levels in the second (OR, 2.84; 95% CI, 1.39-5.79) and third (OR, 2.97; 95% CI, 1.08-8.15) quartiles showed significantly increased odds of meeting our criteria for a diagnosis of glaucoma.

Conclusions and Relevance  Increased daily dietary consumption levels of eicosapentaenoic acid and docosahexaenoic acid were associated with lower likelihood of glaucomatous optic neuropathy. However, consumption levels of total PUFAs in the higher quartiles were associated with a higher risk of glaucoma, which may have resulted from the relative intakes of ω-6 and ω-3 fatty acids and other confounding comorbidities. This study also hypothesizes that increasing the proportion of dietary ω-3 consumption levels while controlling overall daily PUFA intake may be protective against glaucoma. However, longitudinal studies or randomized clinical trials are needed to assess these hypotheses.

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