Fishman Blog

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Role of Resveratrol in Transmitochondrial AMD RPE Cells January 17, 2020 Fishman commentary: Neat finding by Dr. Kuppermann and colleagues. Role of Resveratrol in Transmitochondrial AMD RPE Cells by Sonali Nashine 1, Anthony B. Nesburn 1,2, Baruch D. Kuppermann 1 and Maria Cristina Kenney 1,3,* Nutrients 2020, 12(1), 159; https://doi.org/10.3390/nu12010159 Abstract Resveratrol is a phytoalexin, stilbenoid compound with antioxidant properties attributable to[...] Read More
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Full Length Meibomian Gland Expression January 13, 2020   Dr. Fishman demonstrates a particularly dramatic example of oil expression from the full length of an individual meibomian gland followed by manual expression of it's neighbor. The eyelids were first heated using MiboFlow to "prep" the glands and then manual expression as shown below. Dr. Fishman uses a variety[...] Read More
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Novel, Non-Invasive Method for Addressing Acute and Chronic Chalazia: a case series- Dr. Laura Periman January 12, 2020 Dr. Periman (a.k.a Dry Eye Master - @dryeyemaster) and colleagues present wonderful work on the use of IPL to treat chalazia. As described, IPL shows incredible promise of a drug-free, incision-free and injection-free method of addressing chalazia. IPL was offered to these patients to manage their acute or chronic chalazion/chalazia as[...] Read More
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Debridement-Scaling of a Capped Meibomian Gland January 8, 2020 Dr. Fishman employs a multitude of techniques to treat meibomian gland dysfunction. Debridement-Scaling of a of the eyelid margin is a very effective technique that Dr. Fishman often combines with heating and expressing the eyelid margin (using iLux or MiboFlow).   [videopress P9ABeMjM]   Read More
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Dry Eye as a Mucosal Autoimmune Disease January 7, 2020 Fishman commentary. Classic review article by Dr. Pflugfelder. We need to better understand the innate immune system - " the field is rapidly realizing the complexity of other innate and adaptive immune factors involved in the development and progression of disease" Authors: Michael E. Stern, Chris S. Schaumburg & Stephen[...] Read More
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Probing and expressing a meibomian gland pre-stye January 4, 2020 In this video, Dr. Fishman uses a Maskin Probe to first probe then express an inspissated meibomian gland.  The beginning of the video shows how expressing the inspissated meibomian gland alone does not produce meibum. After probing the gland, milky meibum is expressed.   [videopress MgKnELLT]     Read More
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Changes in brainstem excitatory and inhibitory pathways in dry eye syndrome December 31, 2019 Fishman Commentary: In many patients, dry eye disease present with a neuropathic component, which I refer to as the "trigeminal ganglion pain continuum." In this paper, the authors show that changes at the synaptic level in the brainstem occur in dry eye disease. Highlights * Patients with dry eye have[...] Read More
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Effects of Platelet-rich Plasma on Ocular Surface in Patients with Dry Eye Syndrome: Clinico-experimental Analysis December 28, 2019 Fishman commentary: PRP and PRGF (made at FishmanVision) are purified versions of serum tears and may have excellent efficacy in ocular surface disease including dry eye, epithelial defects, chronic inflammation.  This is a nice paper on PRP for dry eye disease. Authors:  Jae Uk Jung, MD,1 Sang Hee Lee, MD,[...] Read More
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High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus December 15, 2019 Dr. Fishman's commentary: Potentially a very powerful steroid sparring way to treat oral Lichen Planus. It would be interesting if we could perform a clinical trial involving high dose curcuminoids for treating Lichen Planus of the conjunctiva. Lichen planus is an autoimmune condition of unknown aetiology affecting the skin and mucous membranes. Conjunctival[...] Read More
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Confocal microscopy of a neuropathic cornea December 6, 2019 Patient with corneal neuropathy from a refractive surgery 7 years ago. Read More