Fishman Blog

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Innate Immune System Drives Dry Eye Disease February 22, 2020 Dr. Fishman shares his insights into how the innate immune system drives dry eye disease. While inflammation plays a key role in the development and amplification of dry eye, Dr. Fishman emphasizes finding the inciting etiology that stimulates the immune response. Often these stimulants can be overnight poor eyelid closure,[...] Read More
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MicroRNA Profiling in Benign and Malignant Conjunctival Melanocytic Lesions February 19, 2020 Fishman comments: The article says it best... "Conjunctival melanoma is a rare tumor with an incidence of 0.2 to 0.8 cases per 1 million people, although the incidence is increasing." "In daily practice, it can be very difficult to distinguish a benign from a malignant melanocytic lesion based on only[...] Read More
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Female mouse tears contain an anti-aggression pheromone February 17, 2020 Fishman comments: Super interesting article on the effects of female mouse tear fluid on male behavior. The authors found that female tears contain a factor that strongly inhibits inter-male aggression. Cavaliere, R.M., Silvotti, L., Percudani, R. et al. Female mouse tears contain an anti-aggression pheromone. Sci Rep 10, 2510 (2020). https://doi.org/10.1038/s41598-020-59293-9[...] Read More
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Thinking of Dry Eye as a Systemic Disease February 9, 2020 Dry eye is often a sign of chronic inflammatory systemic disease. It is crucial that the when evaluating and treating patients for dry eye, that we take a step back from the slit lamp and focus on systemic inflammatory etiologies.   [videopress CRNOwl5N]   Read More
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How treating dry eye disease could save your patient’s life February 9, 2020 One of the most important opportunities that we have as ophthalmologists is identifying systemic disease through the eye exam. Sometimes, we can actually improve a person's systemic health by treating eye disease. In this short video clip from a presentation in Bermuda, Dr. Fishman explains how treating dry eye disease[...] Read More
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Mmp-9 positive : Chalazion February 6, 2020 Matrix metalloproteinases (MMPs) are a group of enzymes that in concert are responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover. Presence of MMP-9 in the tear film indicates an inflammatory process. The MMP-9 detector shown below is a nice way to track[...] Read More
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Death by IPL January 29, 2020 Fishman comments: Our paper is the first to show direct evidence of "Demodex Death by IPL" using live video microscopy.   Honored to collaborate on this important work with Dr. Periman (aka @dryeyemaster) and Dr. Shah (@sfgotox). Photobiomodul Photomed Laser Surg. 2020 Jan 27. doi: 10.1089/photob.2019.4737. [Epub ahead of print] Real-Time[...] Read More
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Dietary restriction increases protective gut bacteria to rescue lethal methotrexate-induced intestinal toxicity January 27, 2020 Fishman comments: Methotrexate is a commonly used drug to treat various ocular autoimmune conditions including  uveitis and scleritis. Unfortunately, GI side effects are a problem. This is a nice paper exploring the possibility of reducing GI toxicity by  increasing the protective intestinal microbiota. Hopefully, we will continue to understand the[...] Read More
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How I approach the “Hey Doc, these glasses don’t work” – Part I , optics January 25, 2020 This is a very common comment that eye care professionals hear from their patients and thus an excellent opportunity to unpack many important issues in ophthalmology and optometry. I am going to break this into several blog posts and part (I) will start with optics. Future blog posts will focus[...] Read More
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To plug or not to plug, that is the question January 24, 2020 The American Academy of Ophthalmology (AAO) publishes guidelines called preferred practice patterns (PPP). In the staged management of dry eye disease as per the PPP, punctal occlusion (plugs) for dry eye disease has been a level II (step 2) option for many years. It has been an excellent solution for[...] Read More