Fishman Blog

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Changes in brainstem excitatory and inhibitory pathways in dry eye syndrome December 31, 2019 Fishman Commentary: In many patients, dry eye disease present with a neuropathic component, which I refer to as the "trigeminal ganglion pain continuum." In this paper, the authors show that changes at the synaptic level in the brainstem occur in dry eye disease. Highlights * Patients with dry eye have[...] Read More
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Effects of Platelet-rich Plasma on Ocular Surface in Patients with Dry Eye Syndrome: Clinico-experimental Analysis December 28, 2019 Fishman commentary: PRP and PRGF (made at FishmanVision) are purified versions of serum tears and may have excellent efficacy in ocular surface disease including dry eye, epithelial defects, chronic inflammation.  This is a nice paper on PRP for dry eye disease. Authors:  Jae Uk Jung, MD,1 Sang Hee Lee, MD,[...] Read More
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High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus December 15, 2019 Dr. Fishman's commentary: Potentially a very powerful steroid sparring way to treat oral Lichen Planus. It would be interesting if we could perform a clinical trial involving high dose curcuminoids for treating Lichen Planus of the conjunctiva. Lichen planus is an autoimmune condition of unknown aetiology affecting the skin and mucous membranes. Conjunctival[...] Read More
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Confocal microscopy of a neuropathic cornea December 6, 2019 Patient with corneal neuropathy from a refractive surgery 7 years ago. Read More
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MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice December 6, 2019 Fishman Comments: Incredibly interesting work on stem cell transplantation for restoring the lacrimal gland function. MSC in 2 µl saline were injected into the LG. Important basic science in the field of dry eye disease. Authors: Jana Dietrich, Lolita Ott, Mathias Roth, Joana Witt,Gerd Geerling, Sonja Mertsch& Stefan Schrader  Scientific Reports[...] Read More
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Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms November 24, 2019 Fishman commentary: This study provides the first demonstration that corneal inflammation induces activation of pathways within sensory trigeminal complex. These results suggest that this altered activity in intracellular signaling caused by ocular inflammation might play a priming role in the central sensitization of ocular related brainstem circuits, which represents a[...] Read More
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Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction November 20, 2019 Fishman Commentary: The research on the microbiome of the eye continues to show potential avenues for treating chronic ocular conditions such as dry eye disease. In this study,  they found that patients with MGD can have various degrees of bacterial microbiota imbalance in the conjunctival sac. Staphylococcus, Corynebacterium, and Sphingomonas may play roles[...] Read More
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Nonsteroid management of residual ocular surface disease on dupilumab (ROSDD) November 18, 2019 Fishman commentary: Treatment pearls for dupilumab associated ocular surface disease. Authors: JodieRaffiabRaaginiSureshaTimothyBergeraHarveyFishmancJenny E.Murasead https://doi.org/10.1016/j.ijwd.2019.08.007 International Journal of Women's Dermatology . Available online 24 August 2019.   Dear Editors, Atopic dermatitis is associated with a range of ocular complications. Additionally, an increase in dupilumab-associated conjunctivitis, dry eye, and recently characterized residual[...] Read More
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Investigating the role of allergic contact dermatitis in residual ocular surface disease on dupilumab (ROSDD) November 17, 2019 Fishman commentary. Excellent article on ocular surface disease and dupilumab.  Significant improvement after patch testing in nearly half of patients suggests that allergic contact dermatitis contributes to some cases of dupilumab-associated eye complications. Click here for PDF Authors:  JodieRaffiabRaaginiSureshaHarveyFishmancNinaBottoaJenny E.Murasead Abstract Background The mechanisms underlying eye-related complications with dupilumab are[...] Read More
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Eyeliner Induces Tear Film Instability and Meibomian Gland Dysfunction November 16, 2019 Dr. Fishman commentary: Makeup can be toxic to the meibomian glands and can result in tear film abnormality. This is further evidence that patients with dry eye disease need to consider makeup very seriously.----------------------------------------- Published ahead of print in Cornea, Nov 2019. Authors: Prabhasawat, Pinnita MD*; Chirapapaisan, Chareenun MD*; Chitkornkijsin,[...] Read More