Fishman Blog

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MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice December 6, 2019 Fishman Comments: Incredibly interesting work on stem cell transplantation for restoring the lacrimal gland function. MSC in 2 µl saline were injected into the LG. Important basic science in the field of dry eye disease. Authors: Jana Dietrich, Lolita Ott, Mathias Roth, Joana Witt,Gerd Geerling, Sonja Mertsch& Stefan Schrader  Scientific Reports[...] Read More
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Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms November 24, 2019 Fishman commentary: This study provides the first demonstration that corneal inflammation induces activation of pathways within sensory trigeminal complex. These results suggest that this altered activity in intracellular signaling caused by ocular inflammation might play a priming role in the central sensitization of ocular related brainstem circuits, which represents a[...] Read More
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Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction November 20, 2019 Fishman Commentary: The research on the microbiome of the eye continues to show potential avenues for treating chronic ocular conditions such as dry eye disease. In this study,  they found that patients with MGD can have various degrees of bacterial microbiota imbalance in the conjunctival sac. Staphylococcus, Corynebacterium, and Sphingomonas may play roles[...] Read More
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Nonsteroid management of residual ocular surface disease on dupilumab (ROSDD) November 18, 2019 Fishman commentary: Treatment pearls for dupilumab associated ocular surface disease. Authors: JodieRaffiabRaaginiSureshaTimothyBergeraHarveyFishmancJenny E.Murasead https://doi.org/10.1016/j.ijwd.2019.08.007 International Journal of Women's Dermatology . Available online 24 August 2019.   Dear Editors, Atopic dermatitis is associated with a range of ocular complications. Additionally, an increase in dupilumab-associated conjunctivitis, dry eye, and recently characterized residual[...] Read More
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Investigating the role of allergic contact dermatitis in residual ocular surface disease on dupilumab (ROSDD) November 17, 2019 Fishman commentary. Excellent article on ocular surface disease and dupilumab.  Significant improvement after patch testing in nearly half of patients suggests that allergic contact dermatitis contributes to some cases of dupilumab-associated eye complications. Click here for PDF Authors:  JodieRaffiabRaaginiSureshaHarveyFishmancNinaBottoaJenny E.Murasead Abstract Background The mechanisms underlying eye-related complications with dupilumab are[...] Read More
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Eyeliner Induces Tear Film Instability and Meibomian Gland Dysfunction November 16, 2019 Dr. Fishman commentary: Makeup can be toxic to the meibomian glands and can result in tear film abnormality. This is further evidence that patients with dry eye disease need to consider makeup very seriously.----------------------------------------- Published ahead of print in Cornea, Nov 2019. Authors: Prabhasawat, Pinnita MD*; Chirapapaisan, Chareenun MD*; Chitkornkijsin,[...] Read More
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Macular pigment optical density is positively associated with academic performance among preadolescent children November 12, 2019 Dr. Fishman comment: 2 interesting take aways- the use of MPOD to track diet and how brain Lutein may be important for cognitive achievement . "This is the first study to demonstrate that retinal L and Z, measured as MPOD, is positively related to academic achievement in children" Published in : Nutr[...] Read More
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Dry Eye Disease Associated with Lower Gut Microbiome Diversity November 6, 2019 Abiya Farhan Baqai; Harvey A. Fishman, MD PhD Abstract Purpose : The human microbiome has been studied for centuries and recently has been associated with health issues ranging from metabolic disorders such as obesity and diabetes to inflammatory disorders such as inflammatory bowel disease.5 However, only recently have associations of[...] Read More
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Why Don’t Yellow Night Vision Glasses Work? by Dr. Robert W. Massof November 6, 2019 Fishman comment: Excellent in JAMA by Hwang et al1 and neat follow-up commentary by Massof. Take home message that Massof makes: "yellow night vision glasses do not live up to their product claims, but more work is needed to better understand and ultimately ameliorate a ubiquitous problem that is growing with[...] Read More
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Corneal Manifestations of Inflammatory Bowel Disease November 1, 2019 Fishman comment: Another interesting manifestation of systemic disease in the eyes. IBD patients have thinner corneas and reduced tears. ABSTRACT Purpose: To evaluate detailed corneal parameters of inflammatory bowel disease (IBD) patients, including Crohn’s disease (CD) and ulcerative colitis (UC) patients, and to assess associations between anterior segment values and[...] Read More